Dry eye was induced by excision of the lacrimal gland and hyperosmotic media.

Among primary lacrimal gland tumors the adenoid-cystic carcinoma is the most common malignant epithelial lesion.

Biopsy of the left lacrimal gland and left inferior rectus revealed fibrosis and lymphocytic infiltration.

Surgical excisions of the left lacrimal gland were performed.

The existence of a gut-eye- lacrimal gland axis-microbiome is discussed.